Bioactive Small Molecules
TARGETMOL CHEMICALS INC PKI-402 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. PKI-402 is a potent PI3K and mTOR inhibitor. PKI-402 inhibits PI3K(alpha) mTOR PI3K(beta) PI3K(delta) and PI3K(gamma) with IC50s of 2 3 7 14 and 16 nM respectively. purity: 100%
Medchemexpress LLC HY-104068 100mg Medchemexpress, Naphthol AS-E CAS:92-78-4 Purity:>98%
Medchemexpress, HY-104068 100mg Naphthol AS-E CAS:92-78-4 Naphthol AS-E is a potent and cell-permeable inhibitor of KIX-KID interaction. Naphthol AS-E directly binds to the KIX domain of CBP (Kd:8.6 µM), blocks the interaction between the KIX domain and the KID domain of CREB with IC50 of 2.26 µM. Naphthol AS-E can be used for cancer research. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical ANTIBODY CYC-116 5mg
A potent Aurora kinase inhibitor (Kis = 8.0 and 9.2 nM for Aurora A and B kinases, respectively); selective over against a panel of CDKs and other kinases, with the exception of Flt-3 (Ki = 44 nM); exhibits broad-spectrum antiproliferative activity against a panel of human cancer cell lines (mean IC50 = 0.54 µM); orally bioavailable
Cayman Chemical ANTIBODY QuarfloxIn 25mg
An inhibitor of RNA polymerase I-mediated transcription; binds to G-quadruplex DNA and inhibits the interaction between ribosomal DNA G-quadruplexes and nucleolin; induces nucleolin mislocalization from the nucleoli to the nucleoplasm in A549 cells at 10 µM; induces apoptosis in A549 and HL-60 cells at 5 µM; reduces tumor growth in MDA-MB-231 and MiaPaCa-2 mouse xenograft models at 5 mg/kg
Medchemexpress LLC PROTAC(H-PGDS)-7 | 2761281-50-7 | 99.4% | 742.78 | 50 MG
PROTAC(H-PGDS)-7 is a Hematopoietic prostaglandin D synthase (H-PGDS) molecular glue degrader. It exhibits a DC50 of 17.3 pM and demonstrates potent suppression of prostaglandin D2 (PGD2) production in KU812 cells.
- Functions as a hematopoietic prostaglandin D synthase (H-PGDS) molecular glue degrader
- DC50 of 17.3 pM
- Potently suppresses prostaglandin D2 (PGD2) production in KU812 cells
Cayman Chemical ANTIBODY KAS 08 5mg
A STING activator (EC50 = 0.33 µM in a reporter assay using THP-1 human monocytes); increases IFN-β and IP-10 levels in the presence, but not absence, of cGAMP; reduces the viability of CT26 cells at 0.31-20 µM; reduces tumor growth in a CT26 mouse syngeneic model at 15 mg/kg when used in combination with 2’3’-cGAMP
![Medchemexpress LLC 3-[(2,6-dimethylphenoxy)methyl]-4-methoxybenzaldehyde | 438530-82-6 | 97.7% | 270.33 | C17H18O3 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000280836.png-250.jpg)
Medchemexpress LLC 3-[(2,6-dimethylphenoxy)methyl]-4-methoxybenzaldehyde | 438530-82-6 | 97.7% | 270.33 | C17H18O3 | 50 MG
3-[(2,6-dimethylphenoxy)methyl]-4-methoxybenzaldehyde is a synthetic chemical intermediate used in medicinal chemistry for the preparation of active pharmaceutical candidates. It is characterized by formula C17H18O3 and molecular weight 270.33 g/mol, and is supplied with quality documentation for research applications.
- Chemical intermediate for synthesis of active compounds.
- Molecular formula C17H18O3.
- Molecular weight 270.33 g/mol.
- High purity - 97.7% (as indicated on COA).
- Available in small-scale quantities suitable for R&D (50 mg to 10 g).
- Documentation includes certificate of analysis and handling information.
Medchemexpress LLC 7-hydroxy-4-phenylcoumarin | 2555-30-8 | MFCD00024080 | 96.9% | 238.24 g/mol | C15H10O3 | 500 MG
7-Hydroxy-4-phenylcoumarin is a coumarin derivative used as a research reagent that functions as a dual inhibitor of aldehyde dehydrogenase-2 (ALDH-2) and monoamine oxidase (MAO). It exhibits reported IC50 values of 1.5 μM (ALDH-2) and 0.5 μM (MAO) and is supplied as a solid and as DMSO solutions at high purity.
- Dual ALDH-2 and MAO inhibitor with low-micromolar potency.
- High purity solid suitable for research applications.
- Available in multiple pack sizes, including 500 mg solid.
- Also supplied as a ready-to-use 10 mM solution in DMSO.
- Molecular formula C15H10O3; molecular weight 238.24 g/mol.
Medchemexpress LLC PROTAC HSP90 degrade 100mg | 2669072-88-0 | 641.08 | C32H29ClN8O5 | 100 MG
PROTAC HSP90 degrader BP3 is a research-grade PROTAC that induces CRBN-dependent degradation of heat shock protein 90 (HSP90). It shows potent cellular activity (DC50 ≈ 0.99 μM in MCF-7 cells), inhibits growth of several breast cancer cell lines in vitro, and demonstrated tumor growth inhibition in animal studies. Supplied as a solid and as a 10 mM solution in DMSO for laboratory research use only.
- Crbn-dependent HSP90 degradation with DC50 ≈ 0.99 μM in MCF-7 cells.
- Inhibits growth of multiple breast cancer cell lines in vitro.
- Available as solid (5 mg-100 mg) and as 10 mM solution in DMSO.
- High reported purity (~99.5%) with supporting COA, LC-MS, and NMR data.
- Storage recommendations: powder -20°C (long term) and solution -80°C (long term).
Medchemexpress LLC HY-108717 100mg Medchemexpress, Protease K CAS:39450-01-6 Purity:>98%
Medchemexpress, HY-108717 100mg Protease K CAS:39450-01-6 Protease K is a nonspecific serine protease that is useful for general digestion of proteins. Protease K is active in the presence of SDS or urea and over a wide range of pH (4-12), salt concentrations, and temperatures. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Vicenin 3 | 59914-91-9 | MFCD21333257 | 99.9% | 564.49 g·mol⁻1 | C26H28O14 | 10 MG
Vicenin 3 is a high-purity flavonoid C-glycoside supplied as a small-scale research standard suitable for biochemical, pharmacological, and analytical studies. It is commonly used as an analytical reference and in assays investigating angiotensin-converting enzyme (ACE) activity.
- High purity: 99.9% suitable for analytical applications.
- Defined identity: CAS 59914-91-9 and formula C26H28O14.
- Convenient pack size: 10 MG for preliminary experiments and method development.
- Solid form: easy storage and handling under standard laboratory conditions.
- Applicable to biochemical assays and ACE inhibition studies.
Medchemexpress LLC Orelabrutinib (ICP-022) | 1655504-04-3 | 100.0% | 100 MG
Orelabrutinib is a potent, orally active, and irreversible Bruton's tyrosine kinase (BTK) inhibitor with potential antineoplastic activity. It prevents both the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated activation of downstream survival pathways, thereby inhibiting the growth of malignant B-cells that overexpress BTK.
- Potent, orally active, and irreversible BTK inhibitor
- Prevents B-cell antigen receptor (BCR) signaling pathway activation
- Inhibits BTK-mediated activation of downstream survival pathways
- Inhibits the growth of malignant B-cells that overexpress BTK
- Purity of 99.97%
- Soluble in DMSO at 100 mg/mL
Medchemexpress LLC HY-W054146 50mg Medchemexpress, PTP1B-IN-9 CAS:145888-79-5 Purity:>98%
Medchemexpress, HY-W054146 50mg PTP1B-IN-9 CAS:145888-79-5 PTP1B-IN-9 is a ubiquitin-proteasome system (UPS)-stressor. PTP1B-IN-9 inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activites. PTP1B-IN-9 triggers a ubiquitin-proteasome-system (UPS)-stress response without affecting 20S proteasome catalytic activities. Anticancer activity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Apexbio Technology LLC K03861 853299-07-7 5mg
K03861 (CAS 853299-07-7) is a small molecule inhibitor targeting cyclin-dependent kinase 2 (CDK2) Acting as a type II inhibitor of CDK2 K03861 interacts with regions beyond the ATP binding pocket and can antagonize cyclin binding X-ray crystallography studies have demonstrated that K03861 establishes a distinctive binding conformation with CDK2 distinct from type I inhibitors Given the central role of CDK2 in cell cycle regulation proliferation and transcription K03861 provides a valuable chemical tool for investigating the structure function and inhibition of cyclin CDK2 complexes in cellular proliferation and cancer research
Cayman Chemical ANTIBODY A-841720 1mg
A noncompetitive antagonist of mGluR1 (IC50 = 10.7 nM); selective over mGluR5 (IC50 = 343 nM), mGluR2, mGluR4, and mGluR7; selective over a panel of other G-coupled protein receptors as well as ligand- and voltage-gated ion channels at a concentration of 10 µM; dose-dependently inhibits complete Freund's adjuvant-induced inflammatory pain (ED50 = 23 µmol/kg) and sciatic nerve injury-induced mechanical allodynia (ED50 = 28 µmol/kg) in rats; enhances cocaine seeking in mice after a prolonged abstinence following a single conditioning session (10 mg/kg)